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It belongs to a group of medications called phosphodiesterase type 5 (PDE5) inhibitors, which work as vasodilators and cause blood vessels to relax. Viagra can’t permanently cure ED, but it can help in the short-term and is safe to take every day if approved by a doctor. After taking Viagra, most men will be able to maintain an erection for about two to three hours before the effects start to wear off. Viagra is not available over-the-counter and must be prescribed by a physician.
Studies in vitro have shown that sildenafil is selective for PDE5, which is involved in the erection process. Its effect is more potent on PDE5 than on other known phosphodiesterases. There is a 10-fold selectivity over PDE6 which is involved in the phototransduction pathway in the retina. At maximum recommended doses, there is an 80-fold selectivity over PDE1, and over 700-fold over PDE2, 3, 4, 7, 8, 9, 10 and 11. In particular, sildenafil has greater than 4,000-fold selectivity for PDE5 over PDE3, the cAMP-specific phosphodiesterase isoform involved in the control of cardiac contractility. As dizziness and altered vision were reported in clinical trials with sildenafil, patients should be aware of how they react to VIAGRA, before driving or operating machinery.
As with any drug, never change your dosage of Viagra without your doctor’s recommendation. If you have questions about the dosage of Viagra that’s right for you, talk with your doctor. Doing this can increase your risk for serious side effects. Due to age-differences in plasma protein binding, the corresponding increase in free sildenafil plasma concentration was approximately 40%. In healthy volunteers receiving sildenafil (100 mg single dose), less than 0.0002% (average 188 ng) of the administered dose was present in ejaculate 90 minutes after dosing.
In fixed dose studies the 100mg dosage of Sildenafil was found to improve erections for 82% of patients. This is slightly higher than the 50mg dosage (74%) and the 25mg dosage (62%). If you’re being introduced to Viagra for the first time you’ll likely start with the sildenafil 50mg tablet. This is the median dose and is the recommended dose of Viagra for most men.
You might start on the 50mg sildenafil dose but other dosages are available. The recommended dose is one tablet taken about one hour before you plan to have sex. Parents and babies will appreciate the range of products on offer at Medilife Pharmacy. You can find infant formula milk or baby food for growing children from all top brands like Similac, Pediasure, Nestle, etc. Baby skin care products like sunscreen are vital to protect your sensitive skin during the hot summers. Affordable and quality diapers from Pampers &